| Number | Date;Time | Location | level | Home | Away | Status |
| 4675 | 8/20/2021 Fri 6:00 PM | Henry Clay High School, Football Stadium | Football, Varsity 7-Man | Lafayette High Sch… | Conner High School | Normal |
| 4721 | 8/20/2021 Fri 6:00 PM | East Jessamine High School, Stadium | Football, Varsity 7-Man | West Jessamine Hig… | Paul Laurence Dunb… | Normal |
| 4729 | 8/20/2021 Fri 6:00 PM | Scott County High School, Community Football Stadium | Football, Varsity 7-Man | Scott County High … | Franklin County Hi… | Normal |
| 4836 | 8/20/2021 Fri 6:30 PM | Bryan Station High School, Stadium | Football, Varsity | Bryan Station Trad… | Frederick Douglass… | Normal |
| 4809 | 8/20/2021 Fri 7:30 PM | Anderson County High School, Stadium | Football, Varsity | Anderson County Hi… | Spencer County Hig… | Normal |
| 4832 | 8/20/2021 Fri 7:30 PM | George Rogers Clark High School, Stadium | Football, Varsity | George Rogers Clar… | Cooper High School | Normal |
| 4693 | 8/20/2021 Fri 7:30 PM | Madison Central High School, Stadium | Football, Varsity | Madison Central Hi… | Lexington Christia… | Normal |
| 4705 | 8/20/2021 Fri 7:30 PM | Berea High School, Football Stadium | Football, Varsity | Berea Community Hi… | Harlan High School | Normal |
| 4667 | 8/20/2021 Fri 7:30 PM | Frankfort High School, Stadium | Football, Varsity | Frankfort High Sch… | Paris High School | Normal |
| 4674 | 8/20/2021 Fri 8:45 PM | Henry Clay High School, Football Stadium | Football, Varsity 7-Man | Henry Clay Senior … | Johnson Central Hi… | Normal |
| 4735 | 8/20/2021 Fri 8:45 PM | Birds Nest Stadium Georgetown, Community Football Stadium | Football, Varsity | Great Crossing HS | Western Hills High… | Normal |
| 4659 | 8/20/2021 Fri 8:45 PM | East Jessamine High School, Stadium | Football, Varsity 7-Man | East Jessamine Hig… | Bourbon County Hig… | Norma |
| Number | Date;Time | Location | level | Home | Away | Status |
| 4681 | 8/21/2021 Sat 5:00 PM | Mercer County High School, Alvis Johnson Field | Football, Varsity 7-Man | Boyle County High … | Tates Creek High S… | Normal |
| 4716 | 8/21/2021 Sat 7:30 PM | Montgomery County High School, Stadium | Football, Varsity | Montgomery County … | East Carter High S… | Normal |
| 4771 | 8/21/2021 Sat 7:45 PM | Mercer County High School, Alvis Johnson Field | Football, Varsity 7-Man | Mercer County High… | Madison High Schoo… | Normal |
